Scientist - Protein Biochemist - Thousand Oaks CA
Company: Msccn
Location: Thousand Oaks
Posted on: April 3, 2026
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Job Description:
ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization
works with partner companies to source qualified talent for their
open roles. The following position is available to Veterans,
Transitioning Military, National Guard and Reserve Members,
Military Spouses, Wounded Warriors, and their Caregivers . If you
have the required skill set, education requirements, and
experience, please click the submit button and follow the next
steps. Unless specifically stated otherwise, this role is "On-Site"
at the location detailed in the job post. Scientist – Protein
Biochemist What you will do Let’s do this. Let’s change the world.
In this vital role you will be responsible for designing, planning,
and executing the generation of key enabling reagents that support
the structure determination of target molecules via X-ray
crystallography and/or cryo-electron microscopy (cryo-EM). You will
collaborate closely with structural biologists within the group and
contribute to advancing our drug discovery efforts. The ideal
candidate must possess flexibility in applying their knowledge to
new areas of study and have strong interpersonal and communication
skills to thrive in a collaborative environment. Responsibilities:
Protein Biochemistry: Be actively involved in the design and
execution of molecular cloning and protein expression strategies
with the Amgen Discovery Protein Science team or CROs; design and
execute purification strategies to support the structure
determination of drug targets. Collaborative Support: Work closely
with structural biologists to generate high-quality protein samples
for structural biology techniques, particularly X-ray
crystallography and cryo-EM. Method Development: Develop and
optimize purification protocols and reagents, ensuring high protein
purity, homogeneity, and stability for structural studies.
Characterization and Quality Control: Use biochemical and
biophysical techniques (e.g., SDS-PAGE, Western blot,
spectrophotometry, SEC-MALS, SPR, mass spectrometry) to assess
protein quality and stability. Collaborate with team members to
provide mechanistic insights into the mechanism of action (MOA) of
proteins involved in the associated proteins. Project Management:
Manage multiple projects simultaneously, ensuring they are
completed within timelines while meeting high-quality standards.
Team Communication: Present research finds effectively in both
written and oral formats for internal teams and external
collaborators. Innovative Thinking: Continuously troubleshoot and
optimize experimental workflows, applying creative solutions to
overcome challenges in protein production and purification.
Additional Qualifications/Responsibilities What we expect of you We
are all different, yet we all use our unique contributions to serve
patients. The Scientist we seek is a highly motivated professional
with these qualifications. Basic Qualifications: Doctorate degree
OR Master’s degree and 2 years of Molecular, Structural Biology
experience OR Bachelor’s degree and 4 years of Molecular,
Structural Biology experience Preferred Qualifications: Experience
with microbial systems (e.g., E. coli or yeast) or cell culture
(mammalian or insect cells) for protein expression. Hands-on
experience with biochemical analytical techniques such as
spectrophotometry, SDS-PAGE, Western blot, SEC-MALS, SPR, and basic
mass spectrometry. Familiarity with chromatography systems (e.g.,
Cytiva AKTA, Agilent HPLC) and related software. Expertise in
protein purification methods, including affinity, ion exchange,
hydrophobic interaction (HIC), and size-exclusion chromatography
(SEC). Experience with biophysical characterization of protein
complexes, including techniques like dynamic light scattering (DLS)
and analytical ultracentrifugation (AUC). Experience with
expression and purification of membrane proteins. Strong knowledge
of protein stability, folding, and quality control for structural
studies. Excellent presentation skills (written and oral) to
effectively communicate research results to both scientific and
cross-functional teams. Ability to work independently, manage
multiple projects, and meet deadlines in a collaborative
environment. Demonstrated ability to prioritize tasks and manage
multiple projects efficiently. Salary Range 125,580.00 USD -
155,229.00 USD
Keywords: Msccn, Fullerton , Scientist - Protein Biochemist - Thousand Oaks CA, Science, Research & Development , Thousand Oaks, California
